Four Days Exposure And Reprocessing Therapy For PTSD
نویسندگان
چکیده
Introduction Post-traumatic stress disorder (PTSD) is a debilitating affecting approximately 6% of the population. Current treatments have been shown to efficaciously reduce symptom burden between 30%-50%. However, due high intensity treatment over long period time. drop-out rates are as 50%. Objectives Assess effect one-time ketamine infusion in subanasthetic dosage on PTSD psychotherapy feasibility and massed, four days, esposure focused for PTSd Methods Here, we tested efficacy four-day exposure processing-focused at reducing severity. Twenty-seven participants with chronic were randomized two groups, one receiving subanesthetic dose (0.5mg/kg 40 minutes), other midazolam. Both groups underwent 90-120 minutes daily sessions day after infusion, followed by in-vivo practice. The severity was assessed PCL-5 before end treatment, 30 90 days follow-up. Brain reactivation trauma reminders measured using fMRI Results both decreased 13, 16, 15 points follow-up, respectively, surpassing minimum clinical difference 7.9 points. There no significant reductions groups. brain stories differed group showing decline amygdala hippocampus compared midazolam group, treatment. Image: Conclusions Our results imply comparable this short-term intervention standard trauma-focused psychotherapies, emphasizing its usefulness short effective intervention. Disclosure Interest None Declared
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ژورنال
عنوان ژورنال: European Psychiatry
سال: 2023
ISSN: ['0924-9338', '1778-3585']
DOI: https://doi.org/10.1192/j.eurpsy.2023.1019